Between 18 - 65 Years
A Biomarker-Guided, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients with Treatment Resistant Depression(TRD). Approximately 180 patients with TRD who meet all eligibility criteria will be randomized in a 1:1:1 ratio to receive either Liafensine 1 mg QD, Liafensine 2 mg QD, or placebo QD for 6 weeks.